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Twenty-four-hour survival curves of six MRSA isolates and one MSSA isolate (STA 29213) at mid-exponential phase treated with steady-state concentrations of telavancin (TLV), daptomycin (DAP), or vancomycin (VAN). Each time point represents the mean values of the two replicates with standard deviations.

Journal: Microbiology Spectrum

Article Title: In vitro persistence of clinical methicillin-resistant Staphylococcus aureus isolates from bone and joint infections after exposure to daptomycin, telavancin, and vancomycin

doi: 10.1128/spectrum.01576-25

Figure Lengend Snippet: Twenty-four-hour survival curves of six MRSA isolates and one MSSA isolate (STA 29213) at mid-exponential phase treated with steady-state concentrations of telavancin (TLV), daptomycin (DAP), or vancomycin (VAN). Each time point represents the mean values of the two replicates with standard deviations.

Article Snippet: Since both 1× and 2× the MIC were able to complete the three passes, the 2× MIC daptomycin concentration was used to provide the highest test concentration that still provided bacterial load to continue the passes over 72 h. The time course of persister development for the six MRSA isolates in addition to the ATCC strain after daptomycin pre-exposure to daptomycin, telavancin, or vancomycin as percent of bacterial burden relative to the respective control time point after 3 days of daptomycin exposure is shown in .

Techniques:

Twenty-four-hour survival curves of six MRSA isolates and one MSSA isolate (STA 29213) at mid-exponential phase after three serial passes of daptomycin (two times MIC) exposure and then treatment with steady-state concentrations of telavancin (TLV), daptomycin (DAP), or vancomycin (VAN). Each time point represents the mean values of the two replicates with standard deviations. The results were capped at 100%.

Journal: Microbiology Spectrum

Article Title: In vitro persistence of clinical methicillin-resistant Staphylococcus aureus isolates from bone and joint infections after exposure to daptomycin, telavancin, and vancomycin

doi: 10.1128/spectrum.01576-25

Figure Lengend Snippet: Twenty-four-hour survival curves of six MRSA isolates and one MSSA isolate (STA 29213) at mid-exponential phase after three serial passes of daptomycin (two times MIC) exposure and then treatment with steady-state concentrations of telavancin (TLV), daptomycin (DAP), or vancomycin (VAN). Each time point represents the mean values of the two replicates with standard deviations. The results were capped at 100%.

Article Snippet: Since both 1× and 2× the MIC were able to complete the three passes, the 2× MIC daptomycin concentration was used to provide the highest test concentration that still provided bacterial load to continue the passes over 72 h. The time course of persister development for the six MRSA isolates in addition to the ATCC strain after daptomycin pre-exposure to daptomycin, telavancin, or vancomycin as percent of bacterial burden relative to the respective control time point after 3 days of daptomycin exposure is shown in .

Techniques: